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Occupational Medicine 1979;29:134-141
© 1979 Society of Occupational Medicine

research-article

Vinyl Chloride: a Review

C.H.B. BINNS, Senior Medical Officer*

BP Oil Limited

The polymerization process for the industrial production of polyvinyl chloride from vinyl chloride was discovered in Germany in the mid 1930s. Since then, both have been produced in increasing quantities. The first cases of occupational acro-osteolysis in workers engaged in the industry were reported some thirty years later in 1963, and the first cases of angiosarcoma of the liver in workers similarly engaged were reported some forty years later in 1974. Intense public and medical interest were aroused and resulted in extensive investigations into the medical problems now seen to be associated with the industry.

The chronology of these events is outlined, and the epidemiological, chemical, histopaihological and biochemical investigations which resulted are briefly reviewed. Finally, possible metabolic processes, which could result in the known clinical manifestations, are discussed.

Dr C. H. B. Binns, Senior Medical Officer, BP Oil Limited, Medical Centre, BP House, Victoria Street, London, SW1E 5NJ.


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