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Occupational Medicine 1982;32:196-200
© 1982 Society of Occupational Medicine

Effects of Beclomethasone Exposure in Industry

Brian L. D. Phillips

Glaxo Operations UK Ltd

A clinical, laboratory and environmental survey was carried out on the effects of exposure of staff to small quantities of a potent corticosteroid (beclomethasone dipropionate) during the industrial processes concerned with its incorporation into aerosol form for therapeutic inhalation. Pharmacological problems such as a marked vasoconstriction withdrawal phenomenon and opportunistic mycosis were clinically manifest, but systemic involvement was lacking. The industrial remedies undertaken are described and assessed. A strong awareness of potentially hazardous topical and systemic effects is essential among all those involved, although the clinical safety of the drug is stressed.

Accepted        1 February 1982


Dr B. L. D. Phillips, Medical Officer, Glaxo Operations UK Ltd, Ware, Hertfordshire


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