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Occupational Medicine 1988;38:77-81
© 1988 Society of Occupational Medicine

research-article

Health Effects among Workers Involved in the Manufacture of Hexachlorocyclohexane

P. CHATTOPADHYAY, A. B. KARNIK, K. N. THAKORE, B. C. LAKKAD, S. K. NIGAM and S. K. KASHYAP

Division of Occupational Medicine
Division of Environmental Carcinogens
National Institute of Occupational Health (Indian Council of Medical Research) Ahmedabad, India

Forty-five male workers exposed to hexachlorocyclohexane (HCH) during its manufacture were studied and compared with 22 matched controls. Twenty-one of the exposed workers worked in packaging and manual transport of HCH. Twenty-four other exposed workers were plant operators. Exposure was mainly through skin.

Results indicate that the neurological symptoms reported were due to recent exposure to HCH and were related to the intensity of exposure.

An increase in leucine aminopeptidase, ornithine carbamyl transaminase, 5'nucleotides and immunoglobulin M levels among the exposed workers is suggestive of some degree of liver damage. A significant increase in total blood HCH and its {alpha}, ß and {gamma} isomers was also observed in these workers. In spite of pronounced exposure to the {alpha}, ß and {gamma} isomers of HCH, signs of severe health impairment were not observed. Further biological monitoring needs to be carried out among such workers exposed to HCH.

Requests for reprints should be addressed to: Dr S. K. Nigam, National Institute of Occupational Health, Meghani Nagar, Ahmedabad-380 016, India


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