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Occupational Medicine 1989;39:141-143
© 1989 Society of Occupational Medicine

research-article

Serum Oncogene Proteins in Hazardous-Waste Workers

P. W. BRANDT-RAUF, STEVEN SMITH, H. L. NIMAN, M. D. GOLDSTEIN and ELISSA FAVATA

Division of Environmental Sciences, Columbia University School of Public Health New York, USA
Progenx Inc., San Diego USA
Division of Environmental Sciences, Columbia University School of Public Health New York, USA
Department of Environmental and Community Medicine, Robert Wood Johnson Medical School Piscataway, USA

Oncogene protein detection may be a valuable molecular epidemiological marker of commitment to the carcinogenic pathway in worker populations exposed to carcinogens. This paper reports the use of serum immunoblotting with monoclonal antibodies to oncogene proteins to screen hazardous waste workers with potential carcinogen exposure who employ state-of-the-art work practices and personal protective equipment to minimize real exposures. Two individuals in this cohort were found to be trace positive for the ras oncogene protein in their serum, but this may have been due to their cigarette smoking. These results are contrasted to previous results in hazardous waste workers with real workplace carcinogen exposures.

Requests for reprints should be addressed to: Dr P. W. Brandt-Rauf, Director, Occupational Medicine, Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Avenue, B-1 Level, New York, New York 10032, USA


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