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Occupational Medicine 1990;40:11-14
© 1990 Society of Occupational Medicine

research-article

Serum Oncogene Proteins in Foundry Workers

PAUL W. BRANDT-RAUF, STEVEN SMITH, FREDERICA P. PERERA, HENRY L. NIMAN, WENDY YOHANNAN, KARL HEMMINKI and REGINA M. SANTELLA

Division of Environmental Sciences, Columbia University School of Public Health New York, USA
Progenx Inc. San Diego, USA
Division of Environmental Sciences, Columbia University School of Public Health New York, USA
Institute of Occupational Health Helsinki, Finland
Division of Environmental Sciences, Columbia University School of Public Health New York, USA

A new technique for detecting oncogene activation based on immunoblotting for oncogene proteins in serum has been applied to screen a cohort of foundry workers with well-defined workplace exposures to polycyclic aromatic hydrocarbon carcinogens. Three of the 18 individuals screened were found to have abnormal expression of the proteins of the ras and fes oncogenes. These three individuals were known to have had medium to high workplace exposures to benzo(a)pyrene and to have correspondingly high levels of benzo(a)pyrene-DNA adducts in their peripheral leukocytes. No individuals among the unexposed controls were found to have abnormal serum oncogene protein expression. These results suggest the feasibility of using serum oncogene proteins along with DNA-carcinogen adducts as potential molecular epidemiological markers in exposed worker populations; further, larger scale studies will be necessary to demonstrate the utility of these markers for identifying individuals at risk for the development of malignant disease due to their occupational exposures.

Requests for reprints should he addressed to: Dr. P. W. Brandt-Rauf, Director, Occupational Medicine, Division of Environmental Sciences, Columbia University School of Public Health, 60 Haven Avenue, B-1 Level, New York, NY 10032, USA


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