Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Franco, G.
Right arrow Articles by Fonte, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Franco, G.
Right arrow Articles by Fonte, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Occupational Medicine 1994;44:12-16
© 1994 Society of Occupational Medicine

research-article

Advances in evaluating liver response to operating theatre work: urinary D-glucaric acid as an index of effect

G. Franco and R. Fonte

GF. Cattedra di Medicina del lavoro dell'Università di Modena Modena, Italy

The contribution of operating theatre work to specific diseases is still a controversial matter involving a variety of risk factors. The concept that the liver plays a central role in anaesthetics biotransformation stimulated numerous studies aimed at establishing the occurrence of liver changes and at verifying the relationship between liver disease and anaesthetics. The liver microsomal enzyme system has received particular attention in order to clarify the mechanism involved in anaesthetics hepatotoxicity and an increased microsomal activity has been detected in experimental conditions and in humans. In particular, a significant increase in the excretion of urinary D-glucaric acid (UDGA) in subjects occupationally exposed to anaesthetic mixture was observed. Nevertheless, few results exist about the relationship between UDGA increase and environmental anaesthetic concentration, and mechanisms responsible for UDGA increase still need to be clarified. Attention is focused, however, on the possibility of using UDGA as an index reflecting an adaptation effect (rather than an injury effect), which may represent a more adequate approach for evaluating any change related to working in the operating theatre.

Correspondence and reprint requests to: G. Franco, G.F. Cattedra di Medicina del lavoro dell'Università di Modena, via Campi 287, I-41100 Modena, Italy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.