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Occupational Medicine 1994;44:34-36
© 1994 Society of Occupational Medicine

research-article

Occupational asthma and the chemical properties of low molecular weight organic substances

R. M. Agius*,, R. A. Elton*, L. Sawyer{dagger} and P. Taylor{dagger},{ddagger}

*Department of Public Health Sciences UK
{dagger}Department of Biochemistry, The University of Edinburgh UK

Various low molecular weight substances cause occupational asthma, and there is scope for studying their chemical properties in relation to their propensity to cause this condition. Twenty-nine organic substances (molecular weight <250), with or without oxygen or nitrogen atoms, were compared to control hazardous substances obtained from the list of occupational exposure limits. There were significantly more reactive groups in the active chemicals than in the controls. Carbon to nitrogen double bonds were also significantly over-represented in the active chemicals. If confirmed in a fuller study, these data could yield useful information on the causation of occupational asthma and on the hazard assessment of novel chemical entities.

Correspondence and reprint requests to: Dr R. Agius, Senior Lecturer in Occupational and Environmental Health, The Medical School, Teviot Place, Edinburgh EH8 9AG, UK


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Home page
 Occup. Environ. Med.Home page
J Jarvis, M J Seed, R Elton, L Sawyer, and R Agius
Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds
Occup. Environ. Med., April 1, 2005; 62(4): 243 - 250.
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