Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Porru, S.
Right arrow Articles by Alessio, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Porru, S.
Right arrow Articles by Alessio, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Occupational Medicine 1996;46:41-48
© 1996 Society of Occupational Medicine

The Use of Chelating Agents in Occupational Lead Poisoning

S. Porru and L. Alessio

Institute of Occupational Health, University of Brescia P.le Spedali Civili 1, 25123 Brescia, Italy

Chelating agents have long been used in the pharmacological treatment of lead poisoning, whose management is still a problem, particularly in developing countries. This article reviews the pharmacological properties of dimercaprole, penicillamine, CaNa2EDTA and dimercaprosuccinic acid, examines their indications, contraindications and side effects and discusses the possible use of each drug occupational Pb poisoning. Proposals are also presented for the treatment and follow-up of subjects with signs and symptoms of poisoning and of subjects with low-moderate Pb absorption. CaNa2EDTA seems to be the most reliable and safer chelating agent nowadays available and with a wider spectrum of action. DMSA seems to be promising in the treatment of occupational Pb poisoning. Even though there is no doubt that chelation therapy has significantly contributed to reduce mortality and morbidity from occupational Pb poisoning, the efficacy of this treatment in subjects with subtle neurological or renal damage has not yet been studied properly.

Received       21 February 1995
Accepted       11 April 1995

Correspondence and reprint requests to: L. Alessio, Institute of Occupational Health, University of Brescia, P.le Spedali Civili 1,25123 Brescia, Italy.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Intensive Care MedHome page
D. P. Betten, R. B. Vohra, M. D. Cook, M. J. Matteucci, and R. F. Clark
Antidote Use in the Critically Ill Poisoned Patient
J Intensive Care Med, September 1, 2006; 21(5): 255 - 277.
[Abstract] [PDF]

Home page
 Clin. Chem.Home page
P. Hoet, J.-P. Buchet, L. Decerf, B. Lavalleye, V. Haufroid, and D. Lison
Clinical Evaluation of a Lead Mobilization Test Using the Chelating Agent Dimercaptosuccinic Acid
Clin. Chem., January 1, 2006; 52(1): 88 - 96.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.