Occupational Medicine 52:157-164 (2002)
Copyright © 2002 Society of Occupational Medicine
Renal cell carcinoma and occupational exposure to chemicals in Canada
Surveillance & Risk Assessment, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario; and Health Analysis and Measurement Group, Statistics Canada
The Canadian Cancer Registries Epidemiology Research Group comprises a Principal Investigator from each of the provincial cancer registries involved in the National Enhanced Cancer Surveillance System: Bertha Paulse, MSc, BN, Newfoundland Cancer Foundation; Ron Dewar, MA, Nova Scotia Cancer Registry; Dagny Dryer, MD, Prince Edward Island Cancer Registry; Nancy Kreiger, PhD, Cancer Care Ontario; Heather Whittaker, Manitoba Cancer Treatment and Research Foundation; Diane Robson, BA, Saskatchewan Cancer Foundation; Shirley Fincham, PhD, Division of Epidemiology, Prevention and Screening, Alberta Cancer Board; and Nhu Le, PhD, British Columbia Cancer Agency.
Correspondence to: Dr Yang Mao, Director, Surveillance & Risk Assessment, Centre for Chronic Disease Prevention and Control, Population & Public Health Branch, Health Canada, Tunney's Pasture AL0601C1, Ottawa, Ontario K1A 0L2, Canada. e-mail: yang_mao{at}hc-sc.gc.ca
Abstract
This study assesses the effect of occupational exposure to specific chemicals on the risk of renal cell carcinoma in Canada. Mailed questionnaires were used to obtain data on 1279 (691 male and 588 female) newly diagnosed, histologically confirmed renal cell carcinoma cases and 5370 population controls in eight Canadian provinces, between 1994 and 1997. Data were collected on socio-economic status, smoking habit, alcohol use, diet, residential and occupational histories, and years of exposure to any of 17 chemicals. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived using unconditional logistic regression. The study found an increased risk of renal cell carcinoma in males only, which was associated with occupational exposure to benzene; benzidine; coal tar, soot, pitch, creosote or asphalt; herbicides; mineral, cutting or lubricating oil; mustard gas; pesticides; and vinyl chloride. Compared with no exposure to the specific chemical, the adjusted ORs were 1.8 (95% CI = 1.2–2.6), 2.1 (1.3–3.6), 1.4 (1.1–1.8), 1.6 (1.3–2.0), 1.3 (1.1–1.7), 4.6 (1.7–12.5), 1.8 (1.4–2.3) and 2.0 (1.2–3.3), respectively; an elevated risk was also associated with exposure to cadmium salts and isopropyl oil. The risk of renal cell carcinoma increased with duration of exposure to benzene, benzidine, cadmium, herbicides and vinyl chloride. Very few females were exposed to specific chemicals in this study; further research is needed to clarify the association between occupational exposure to chemicals and renal cell carcinoma in females.
Keywords Chemicals; logistic regression; occupational exposure; odds ratio; renal cell carcinoma
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Karami, P. Boffetta, N. Rothman, R. J. Hung, T. Stewart, D. Zaridze, M. Navritalova, D. Mates, V. Janout, H. Kollarova, et al. Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms Carcinogenesis, August 1, 2008; 29(8): 1567 - 1571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Filipic, T Fatur, and M Vudrag Molecular mechanisms of cadmium induced mutagenicity Human and Experimental Toxicology, February 1, 2006; 25(2): 67 - 77. [Abstract] [PDF]
|
|