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Occupational Medicine 2006 56(3):162-172; doi:10.1093/occmed/kql011
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© The Author 2006. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

IN-DEPTH REVIEW

Medical management of radiation injuries: current approaches

M. E. Berger, D. M. Christensen, P. C. Lowry, O. W. Jones and A. L. Wiley

Radiation Emergency Assistance Center/Training Site (REAC/TS), PO Box 117, Oak Ridge, TN 37831-0117, USA

The current approach to medical management of irradiated patients begins with early diagnosis of radiation injury. Medical assessment of radiation dose is based on event history, symptomatology and laboratory results, with emphasis on time to emesis and lymphocyte depletion kinetics. Dose assessment provides a basis for early use of haematopoietic growth factors that can shorten the period of neutropaenia for patients with acute radiation syndrome. Assessments of haematopoietic, gastrointestinal and cutaneous syndromes have improved in recent years, but treatment options remain limited. Selected examples of current developments are presented.

Keywords      Combined injury; gastrointestinal syndrome; haematopoietic syndrome; internal contamination; local radiation injury; radiation injury; radiation medicine

Correspondence to: Albert Wiley, REAC/TS, PO Box 117, Oak Ridge, TN 37831, USA. e-mail: wileya{at}orau.gov


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