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Occupational Medicine Advance Access originally published online on July 25, 2007
Occupational Medicine 2007 57(7):505-511; doi:10.1093/occmed/kqm066
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Acute symptoms following work with pesticides

Christine Solomon1, Jason Poole1, Keith T. Palmer1, Robert Peveler2 and David Coggon1

1 MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
2 Clinical Neurosciences Division, University of Southampton, Southampton SO16 6YD, UK

Background Serious accidental poisoning by pesticides is rare in the UK, but more minor pesticide-related illness may be under-reported. Anecdotally, use of sheep dip has been linked with flu-like symptoms.

Aim To explore the frequency, nature and determinants of acute symptoms following work with pesticides.

Methods A postal survey of men in three rural areas of England and Wales provided data on occupational use of five categories of pesticide, occurrence of 12 specified symptoms within 48 h of using pesticides and tendency to somatize. Risk factors for pesticide-related symptoms were assessed by modified Cox regression.

Results Of 10 765 responders (response rate = 31%), 4108 had at some time used pesticides occupationally, including 935 (23%) who reported symptoms following such work on at least one occasion. In two areas, acute symptoms were most frequent following use of sheep dip (29 and 32% of users), but in the third area the rate was significantly lower (13% of users). The relative frequency of symptoms was similar for all five categories of pesticide, and flu-like symptoms did not cluster unusually among users of sheep dip. Risk of pesticide-related symptoms increased with somatizing tendency (prevalence ratio for highest versus lowest category 2.4, 95% confidence interval 2.0–3.0) and was higher in men who had used pesticides most often or handled concentrate.

Conclusion Acute symptoms are common following work with pesticides, but in many cases the illness may arise through psychological rather than toxic mechanisms.

Keywords      Fungicides; herbicides; insecticides; poisoning; psychological; sheep dip; somatization; toxicity


Correspondence to: David Coggon, MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton SO16 6YD, UK. Tel: +44 23 80 777624; fax: +44 23 80 704021; e-mail: dnc{at}mrc.soton.ac.uk


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