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Occupational Medicine 2007 57(8):548-551; doi:10.1093/occmed/kqm109
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The immunological principles underlying vaccine-induced protection in the occupational health setting

David Baxter

Epidemiology and Health Sciences, Stopford Building, Manchester University Medical School, Oxford Road, Manchester, UK

Abstract Protection against the large numbers of pathogenic microbes to which humans are constantly exposed is effected through external barriers (skin and mucus membranes), innate barriers (cellular components and soluble chemical mediators) and adaptive barriers (B and T lymphocytes). This article reviews the normal mechanisms employed to protect against these pathogenic microbes.

Keywords      Extracellular pathogens; host defences; innate adaptive systems; intracellular pathogens; occupation

Correspondence to: David Baxter, Epidemiology and Health Sciences, Stopford Building, Manchester University Medical School, Oxford Road, Manchester, UK. e-mail: baxter{at}nhs.net


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