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Occupational Medicine 1992;42:39-42
© 1992 Society of Occupational Medicine

research-article

Serum growth factors and oncoproteins in firefighters

J. Ford, S. Smith, Jiin-Chyuan Luo, G. Friedman-Jimenez, P. Brandt-Rauf, S. Markowitz, K. Garibaldi and H. Niman

Department of Medicine and Division of Environmental Sciences, Columbia University USA
Division of Occupational and Environmental Medicine, Mt Sinai School of Medicine USA
School of Public Health, University of Pittsburgh USA

Firefighters are potentially at increased risk for cancer and non-malignant respiratory disease due to their toxic exposures on the job. Growth factors and oncogene proteins are thought to play a role in the development of various malignancies and pulmonary fibrotic diseases. Therefore, a cohort of firefighters and matched controls have been screened for the presence of nine different growth factors and oncoproteins using an immunoblotting assay. Fourteen of the firefighters were found to be positive for ß-transforming growth factor (ß-TGF) related proteins compared to no positives in the controls (P=0.0017). These results suggest that ß-TGF may be a possible biomarker for monitoring firefighters and other exposed workers for the potential development of cancer or non-malignant respiratory disease.

Correspondence and reprint requests should be addressed to: Dr Paul Brandt-Rauf, Director of Occupational Medicine, Columbia University, School of Public Health, 60 Haven Avenue, B-1 New York, New York 10032, USA


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