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Occupational Medicine 51:507-509 (2001)
Copyright © 2001 Society of Occupational Medicine

Original Paper

Identification of a possible biomarker for colophony exposure

K. Jones, S. J. Garfitt, A. Calverley,, K. Channa and J. Cocker

Health & Safety Laboratory, Broad Lane, Sheffield S3 7HQ, UK
National Centre for Occupational Health, Johannesburg
School of Public Health, University of Witwatersand, Johannesburg, South Africa

Abstract

Colophony is known to cause occupational asthma and dermatitis. Biological monitoring may be useful in assessing exposure. This paper describes a method for the analysis of dehydroabietic acid in urine and its potential use as a marker of colophony exposure. The method involves hydrolysis, solvent extraction, derivatization and analysis by gas chromatography–mass spectrometry. Twenty-eight workers from a soldering factory in South Africa were monitored. Results showed that levels of dehydroabietic acid in urine may be correlated with a subjective assessment of exposure.

Keywords      Biological monitoring; colophony; occupational exposure; rosin; urine


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