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Occupational Medicine 2005 55(7):572-574; doi:10.1093/occmed/kqi120
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Short Report

Glutaraldehyde-induced occupational asthma: BALF components and BALF and serum Clara cell protein (CC16) changes due to specific inhalatory provocation test

Cezary Palczynski1, Jolanta Walusiak1, Anna Krakowiak1, Tadeusz Halatek2, Urszula Ruta1, Patrycja Krawczyk-Adamus1, Tomasz Wittczak1, Radoslaw Swiercz2, Pawel Gorski3 and Konrad Rydzynski2

1 Department of Occupational Diseases, Centre of Occupational and Environmental Allergy, Nofer Institute of Occupational Medicine, 8 Teresy St, 90-950 Lodz, Poland
2 Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8 Teresy St, 90-950 Lodz, Poland
3 Division of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland

Objectives The purpose of this study was to evaluate bronchoalveolar lavage fluid (BALF) components and Clara cell protein (CC16) concentration in serum and BALF in patients with glutaraldehyde (GA)-induced asthma, before and after a specific inhalatory provocation test (SIPT) with GA, in comparison to atopic asthmatics and healthy individuals.

Methods Spirometry and bronchoalveolar lavage were performed before and after SIPT. The serum and BALF concentrations of CC16 and cytogram content in BALF were evaluated.

Results In GA-sensitized asthmatics, the level of CC16 in BALF and serum was significantly lower at 24 h after SIPT in comparison with the values recorded prior to the experiment. There was a significant increase in the proportion of eosinophils, basophils and lymphocytes in BALF of GA-sensitized asthmatics obtained after SIPT.

Conclusions The determination of CC16 either in serum or in BALF is a non-invasive test to detect Clara cell damage.

Keywords      Bronchoalveolar lavage; CC16; glutaraldehyde; occupational asthma

Correspondence to: Anna Krakowiak, Department of Occupational Diseases, Centre of Occupational and Environmental Allergy, Nofer Institute of Occupational Medicine, 8 Teresy St, 90-950 Lodz, Poland. e-mail: annakrak{at}imp.lodz.pl


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