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Occupational Medicine Advance Access published online on October 17, 2006
Occupational Medicine, doi:10.1093/occmed/kql104
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© The Author 2006. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Short Report

University of Toronto case-control study of multiple chemical sensitivity-3: intra-erythrocytic mineral levels

Cornelia J. Baines 1 *, Gail E. McKeown-Eyssen 2, Nicole Riley 1, Lynn Marshall 3, and Vartouhi Jazmaji 1

1 Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
2 Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
3 Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada

* To whom correspondence should be addressed.
Cornelia J. Baines, E-mail: cornelia.baines{at}utoronto.ca


  Abstract

Background Multiple chemical sensitivity (MCS) has an estimated American prevalence of 15%, and no consistently abnormal laboratory tests are available to assist in its diagnosis. Some physicians treating MCS patients have observed changes in intra-erythrocytic minerals (IEMs). As co-factors, minerals could influence detoxication of xenobiotics.

Aim To test whether IEM differed comparing MCS cases with controls.

Methods A total of 408 women meeting validated inclusion and exclusion criteria for MCS participated in this case-control study.

Results No statistically significant differences were observed. However, for copper, chromium, magnesium, molybdenum, sulphur and zinc, mean detectable levels were all lower in cases. No dose-response relationships were found.

Conclusion IEM measurements do not appear to provide useful diagnostic markers for MCS.

Keywords: Chemical intolerance; environmental intolerance; hypersensitivity; MCS; minerals.
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