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Occupational Medicine Advance Access published online on March 30, 2009
Occupational Medicine, doi:10.1093/occmed/kqp046
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© The Author 2009. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Short Report

Lung cancer mortality in arsenic-exposed workers from a cadmium recovery plant

Tom Sorahan

Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Background There is evidence that arsenic is a late-stage human lung carcinogen.

Aim To investigate lung cancer risks in a cohort of cadmium recovery workers in relation to period from ceasing exposure to arsenic.

Method The mortality experience (1940–2001) of a cohort of 625 male workers from a US cadmium recovery plant was compared with expectations based on US national mortality rates.

Result There was a statistically significant (P < 0.05) negative trend in lung cancer standardized mortality ratios in relation to period from ceasing arsenic exposure.

Conclusion The findings are consistent with the hypothesis that arsenic is a late-stage human carcinogen.

Keywords      Arsenic; cadmium; cohort study; lung cancer

Correspondence to: Tom Sorahan, Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Tel: +44 121 414 3644; fax: +44 121 414 6217; e-mail: t.m.Sorahan{at}bham.ac.uk


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