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Occupational Medicine Advance Access published online on June 29, 2009
Occupational Medicine, doi:10.1093/occmed/kqp093
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© The Author 2009. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cancer incidence and exposure to 4,4'-methylene-bis-ortho-chloroaniline (MbOCA)

Abid Dost1, J. K. Straughan2 and Tom Sorahan3

1 British Rubber and Polyurethane Products Association Limited, 6 Bath Place, Rivington Street, Bath Place, London EC2A 3JE, UK
2 Occupational Health and Screening Services, Cleeton Court, Cleeton St Mary, Kidderminster, Worcestershire DY14 0QZ, UK
3 Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Aims To monitor the occurrence of cancer in a recently defined cohort of UK workers engaged in the manufacture of polyurethane elastomers using 4,4'-methylene-bis-ortho-chloroaniline.

Methods A cohort of 308 male production workers from seven factories have been enumerated. All employees had a minimum of 12 months employment and were first employed at one of the participating factories in the period 1973–2000. Mortality and cancer incidence data for the period 1979–2007 were compared with expected values based on national rates.

Results Mortality from all cancers combined was below the expected value [observed (Obs) 5, standardized mortality ratio (SMR) 68]. There was a single death from bladder cancer (SMR 560). The incidence of all cancers combined was also below expectation [Obs 9, standardized registration ratio (SRR) 77]. Site-specific incidence was unexceptional except there was a non-significant excess of bladder cancer based on two cases (SRR 328).

Conclusions The findings for bladder cancer should be treated with caution as they relate to a relatively early period of follow-up and are based on very small numbers.

Keywords      Bladder cancer; MbOCA; 4,4'-methylene-bis-ortho-chloroaniline; polyurethane elastomers

Correspondence to: Abid Dost, British Rubber and Polyurethane Products Association Limited, 6 Bath Place, Rivington Street, Bath Place, London EC2A 3JE, UK. Tel: +44 (0)20 7457 5040; fax: +44 (0)20 7972 9008; e-mail: adost{at}brppa.co.uk


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